DESCRIPTION: Pramipexole is a type of medication called a dopamine agonist. It works by stimulating dopamine receptors in the brain, which helps to reduce the production of prolactin, a hormone that can be too high in certain conditions. By activating these receptors, pramipexole can help manage conditions related to excess prolactin.
Mechanism of Action:
1.? ?Stimulates dopamine receptors: Pramipexole binds to D2 and D3 receptors, mimicking dopamine’s effect.
2.? ?Inhibits prolactin secretion: Dopamine suppresses prolactin release from the pituitary gland.
3.? ?Reduces prolactin synthesis: Pramipexole decreases prolactin mRNA expression.
Benefits for Prolactin Control:
1.? ?Decreases prolactin levels: Effective in managing hyperprolactinemia (elevated prolactin).
2.? ?Relieves symptoms: Reduces or eliminates symptoms like: – Gynecomastia (male breast tissue growth) – Galactorrhea (spontaneous milk production) – Infertility – Erectile dysfunction – Fatigue
3.? ?Enhances dopamine function: Pramipexole’s dopaminergic activity may improve mood, motivation, and cognitive function.
Clinical Applications:
1.? ?Hyperprolactinemia treatment
2.? ?Prolactinoma management (benign pituitary tumor)
3.? ?Parkinson’s disease treatment (off-label use)
4.? ?Bodybuilding and athletic performance (off-label use) Dosage and Administration:
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